Masuo Yamaoka Selected Research

orteronel

11/2013	Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys.
4/2012	Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.
11/2011	Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

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Masuo Yamaoka Research Topics

Disease

12	Prostatic Neoplasms (Prostate Cancer) 03/2013 - 01/2003
8	Neoplasms (Cancer) 12/2017 - 09/2003
3	Sarcopenia 01/2020 - 05/2015
3	Cachexia 12/2017 - 05/2015
2	Body Weight (Weight, Body) 01/2020 - 12/2017
2	Disease Progression 04/2012 - 09/2010
1	Hypogonadism (Hypergonadotropic Hypogonadism) 05/2015
1	Neoplasm Metastasis (Metastasis) 09/2003

Drug/Important Bio-Agent (IBA)

9	Androgen Receptors (Androgen Receptor)IBA 12/2017 - 09/2003
6	AndrogensIBA 03/2013 - 01/2003
4	Testosterone (Sustanon)FDA Link 01/2020 - 09/2003
4	Anabolic AgentsIBA 01/2020 - 05/2015
3	orteronelIBA 11/2013 - 11/2011
3	Hormones (Hormone)IBA 11/2013 - 09/2003
3	bicalutamide (Casodex)FDA LinkGeneric 01/2013 - 01/2012
2	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 04/2012 - 11/2011
2	Dehydroepiandrosterone (DHEA)IBA 04/2012 - 09/2003
2	Androgen Antagonists (Antiandrogens)IBA 11/2005 - 01/2003
1	LipidsIBA 01/2020
1	testosterone enanthate (Delatestryl)FDA LinkGeneric 01/2020
1	serine-glyoxylate aminotransferaseIBA 01/2020
1	Alanine Transaminase (SGPT)IBA 01/2020
1	CholesterolIBA 01/2020
1	HDL CholesterolIBA 01/2020
1	LDL CholesterolIBA 01/2020
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	Lipoprotein(a)IBA 01/2020
1	anamorelinIBA 12/2017
1	Antineoplastic Agents (Antineoplastics)IBA 12/2017
1	ostarineIBA 12/2017
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2017
1	CytokinesIBA 12/2017
1	Ghrelin ReceptorsIBA 12/2017
1	Estradiol (Delestrogen)FDA LinkGeneric 11/2013
1	Estrogens (Estrogen)FDA Link 11/2013
1	AmidesIBA 01/2013
1	SteroidsIBA 04/2012
1	Hydrocortisone (Cortisol)FDA LinkGeneric 04/2012
1	EnzymesIBA 04/2012
1	Androgen Receptor AntagonistsIBA 01/2012
1	PyrrolesIBA 01/2012
1	TubulinIBA 01/2010
1	Docetaxel (Taxotere)FDA Link 01/2010
1	Prostate-Specific Antigen (Semenogelase)IBA 09/2003

Therapy/Procedure

8	Castration 01/2013 - 01/2003
5	Therapeutics 12/2017 - 01/2003